Atomistic Simulations of PAP248-286 Peptide Oligomerization
نویسندگان
چکیده
منابع مشابه
Free-energy landscape of protein oligomerization from atomistic simulations.
In the realm of protein-protein interactions, the assembly process of homooligomers plays a fundamental role because the majority of proteins fall into this category. A comprehensive understanding of this multistep process requires the characterization of the driving molecular interactions and the transient intermediate species. The latter are often short-lived and thus remain elusive to most e...
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Amyloid fibrils contained in semen, known as SEVI, or semen-derived enhancer of viral infection, have been shown to increase the infectivity of HIV dramatically. However, previous work with these fibrils has suggested that extensive time and nonphysiologic levels of agitation are necessary to induce amyloid formation from the precursor peptide (a proteolytic cleavage product of prostatic acid p...
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BACKGROUND Semen is a major vehicle for HIV transmission. Prostatic acid phosphatase (PAP) fragments, such as PAP248-286, in human semen can form amyloid fibrils to enhance HIV infection. Other endogenous or exogenous factors present during sexual intercourse have also been reported to promote the formation of seminal amyloid fibrils. METHODOLOGY AND PRINCIPAL FINDINGS Here, we demonstrated t...
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ژورنال
عنوان ژورنال: U?ënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki
سال: 2022
ISSN: ['2542-064X', '1815-6169', '2500-218X']
DOI: https://doi.org/10.26907/2542-064x.2022.2.185-195